Protein Details: Acid-sensing ion channel 2

Protein ID

ICDB_Pro_0849

Protein Name

Acid-sensing ion channel 2

Gene Name

ASIC2; ACCN; ACCN1; BNAC1; MDEG

Organism

Homo sapiens (Human)

Length

512 amino acids

AlphaFoldDB

AF-Q16515-F1-model_v4.pdb

Function

Cation channel with high affinity for sodium;which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.

Sequence

MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPSVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNHSETISHTVNVPLQTTLGTLEEIAC

PDB Structures

6L6P

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Spastic Paraplegia 41;Autosomal Dominant and Liddle Syndrome 1

Location

Brain and spinal cord. Isoform 1 is also detected in testis;liver;colon and ovary.

DOI ID

10.1074/jbc.271.14.7879; 10.1074/jbc.271.18.10433; 10.1073/pnas.94.4.1459; 10.1186/1471-2164-8-399; 10.1038/nature04689; 10.1101/gr.2596504; 10.1074/jbc.m004114200; 10.1042/0264-6021:3610443; 10.1038/nature11494

RefSeq

NP_001085.2 [Q16515-1]; NP_899233.1 [Q16515-2]